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Individualize and adjust dose according to patient's blood pressure response and tolerance.
Mild to moderate hypertension: Initial dose orally, 75 to 150 mcg twice daily, in the morning and at bedtime
Dose may be increased in increments of 100 mcg/day until optimum response is achieved.
Maintenance Dose: Most common range is 200 to 600 mcg/day given in two divided doses.
Maximum Dose: 2400 mcg/day in two to three divided doses.
Sedative effects may be minimized by giving bulk of the daily dose at bedtime.
Severe hypertension: Increase initial dose to 300 mcg three times daily (900 mcg/day total loading dose)
Or, as prescribed by a physician.
